Life Science Research Laboratory, Japan Tobacco Inc., 6-2 Umegaoka, Midori-ku, 227, Yokohama, Japan.
J Chem Ecol. 1991 Apr;17(4):695-706. doi: 10.1007/BF00994193.
The biological activities of synthetic periplanone analogs, including four candidates of periplanone-A (P-A), were evaluated by behavioral and electroantennogram (EAG) assays. Among 16 periplanone analogs, six compounds evoked pheromonal activity from the male American cockroaches. The threshold dosages of these biological active analogs were 10-10(5) times lower than that of the known periplanone mimic, germacrene-D. The conformation required for eliciting the pheromonal activity is discussed in terms of the structure-activity relationship of these analogs. Hauptmann's P-A elicited the strongest pheromonal activity among four candidates of P-A in our bioassay, suggesting that Hauptmann's P-A is a natural P-A produced from female cockroaches.
合成倍半萜类似物的生物活性，包括倍半萜-A（P-A）的四个候选物，通过行为和触角电位图（EAG）测定进行了评估。在 16 个倍半萜类似物中，有 6 种化合物从雄性美洲蟑螂中诱发出信息素活性。这些生物活性类似物的阈值剂量比已知的倍半萜类似物，大根香叶烯-D 的阈值剂量低 10-10(5)倍。根据这些类似物的结构-活性关系，讨论了引发信息素活性所需的构象。在我们的生物测定中，Hauptmann 的 P-A 在四个 P-A 候选物中表现出最强的信息素活性，表明 Hauptmann 的 P-A 是一种由雌性蟑螂产生的天然 P-A。
