Department of Pediatrics, Nassau County Medical Center, 11554, East Meadow, NY, USA.
Biol Trace Elem Res. 1985 Apr;7(3):169-79. doi: 10.1007/BF02916539.
Male Sprague-Dawley rats were used to determine the effects of suptoxic and toxic concentrations of selenite in the drinking water on tissue distribution of zinc (Zn), iron (Fe), and copper (Cu). Se (as sodium selenite) was provided in drinking water at concentrations of 0, 2, 4, and 8 ppm. At 19 d, half of the rats in 4 and 8 ppm Sesupplemented groups were kept on drinking water alone for additional 13 d. All rats were sacrificed at the end of 32 d of experiment. Heart, liver, and kidney were analyzed for the concentrations of Fe, Zn, and Cu by atomic absorption spectrophotometry and of Se by a fluorometric method.Results indicated that rats receiving 4 and 8 ppm Se in drinking water showed a marked reduction in food intake and a reduced growth rate. These adverse effects were quickly reversed when high Se intake was discontinued. Se toxicity caused minimal change in zinc status, reduced tissue iron concentrations and caused a marked increase in copper contents in heart, liver, and kidney. The latter findings were only partly reversed after removal of Se in drinking water. The accumulation of Cu in the tissues of Se-toxic rats provides the evidence of some interaction between Se and Cu.
雄性 Sprague-Dawley 大鼠被用于确定饮水中亚硒酸盐的毒性和毒性浓度对锌（Zn）、铁（Fe）和铜（Cu）的组织分布的影响。硒（以亚硒酸钠的形式）以 0、2、4 和 8 ppm 的浓度添加到饮用水中。在 19 天，4 ppm 和 8 ppm Se 补充组中的一半大鼠继续单独饮用饮用水 13 天。所有大鼠在实验的第 32 天结束时被处死。通过原子吸收分光光度法分析心脏、肝脏和肾脏中的 Fe、Zn 和 Cu 浓度，以及通过荧光法分析 Se 浓度。结果表明，饮用水中摄入 4 ppm 和 8 ppm Se 的大鼠表现出明显的食物摄入减少和生长速度减慢。当停止高 Se 摄入时，这些不利影响迅速逆转。Se 毒性对锌状态的影响最小，降低了组织铁浓度，并导致心脏、肝脏和肾脏中的铜含量显著增加。在停止饮用含硒水后，这些发现仅部分得到逆转。在 Se 毒性大鼠的组织中铜的积累提供了 Se 和 Cu 之间存在一些相互作用的证据。
