金纽扣愈伤组织中土木香内酯的生物合成

Biosynthesis of rutacridone in tissue cultures of Ruta graveolens L.

机构信息

Institut für Biochemie der Pflanzen, Akademie der Wissenschaften der DDR, DDR-4010 Halle (Saale), Weinberg 3, GDR.

出版信息

Plant Cell Rep. 1982 Jun;1(4):168-71. doi: 10.1007/BF00269190.

Abstract

The dihydrofuroacridone, rutacridone, is the main alkaloid in tissue cultures of Ruta graveolens L. strain R-19. The biosynthesis of this particular acridone alkaloid was investigated by using calluses and suspension cultures of strain R-19. Anthranilic acid is specifically incorporated into ring A of rutacridone. Some further evidence was provided that acetate via a polyketide is involved in acridone biosynthesis. Mevalonic acid gave a poor incorporation into rutacridone. Thus the origin of the isopropyldihydrofuran moiety of the investigated alkaloid is still obscure.

摘要

二氢呋喃并吖啶酮、鲁替卡灵是瑞香狼毒（Ruta graveolens L.）菌株 R-19 组织培养物中的主要生物碱。通过使用菌株 R-19 的愈伤组织和悬浮培养物来研究这种特殊的吖啶酮生物碱的生物合成。邻氨基苯甲酸特异性地掺入到鲁替卡灵的环 A 中。进一步的证据表明，通过聚酮体的乙酸盐参与吖啶酮的生物合成。甲羟戊酸掺入鲁替卡灵的情况较差。因此，所研究的生物碱的异戊二烯二氢呋喃部分的来源仍然不清楚。