Sarvaiya Purvaba J, Guo Donna, Ulasov Ilya, Gabikian Patrik, Lesniak Maciej S
The Brain Tumor Center, The University of Chicago, Chicago, Illinois, USA.
Oncotarget. 2013 Dec;4(12):2171-85. doi: 10.18632/oncotarget.1426.
Chemokines play a vital role in tumor progression and metastasis. Chemokines are involved in the growth of many cancers including breast cancer, ovarian cancer, pancreatic cancer, melanoma, lung cancer, gastric cancer, acute lymphoblastic leukemia, colon cancer, non-small lung cancer, non-hodgkin's lymphoma, etc. The expression of chemokines and their receptors is altered in many malignancies and leads to aberrant chemokine receptor signaling. This review focuses on the role of chemokines in key processes that facilitate tumor progression including proliferation, senescence, angiogenesis, epithelial mesenchymal transition, immune evasion and metastasis.
趋化因子在肿瘤进展和转移中起着至关重要的作用。趋化因子参与多种癌症的生长，包括乳腺癌、卵巢癌、胰腺癌、黑色素瘤、肺癌、胃癌、急性淋巴细胞白血病、结肠癌、非小细胞肺癌、非霍奇金淋巴瘤等。趋化因子及其受体的表达在许多恶性肿瘤中发生改变，并导致趋化因子受体信号异常。本综述重点关注趋化因子在促进肿瘤进展的关键过程中的作用，包括增殖、衰老、血管生成、上皮-间质转化、免疫逃逸和转移。
