Izmaĭlov T R, Pan'shin G A, Misliukov S M, Datsenko P V
Vopr Onkol. 2013;59(5):629-35.
There were showed the possibility of using the model of TDF, through which it was possible to take into account the selection of fractionation of radiation for high-grade gliomas and to judge the effectiveness of treatment. Currently, the basis of adjuvant radiation therapy in patients with primary high-grade gliomas is the use of the traditional mode of fractionation dose of radiation from a single focal dose of 2 Gy up to a total focal dose of 60 Gy to the tumor (bed of the removed residual tumor) in Grade 4 and Grade 3 - 54 Gy. In patients who underwent radiotherapy using a single focal dose of 3 Gy, overall survival rate was higher as compared to the group of patients, which was carried out using radiotherapy small dose fractionation.
结果表明使用TDF模型具有可能性，通过该模型可以考虑高级别胶质瘤放射治疗分割方式的选择并判断治疗效果。目前，原发性高级别胶质瘤患者辅助性放射治疗的基础是采用传统分割剂量模式，即从单次局部剂量2 Gy至4级肿瘤（切除残余肿瘤床）的总局部剂量60 Gy，3级为54 Gy。与采用小剂量分割放射治疗的患者组相比，接受单次局部剂量3 Gy放射治疗的患者总生存率更高。
