Pacific Parkinson's Research Centre, University of British Columbia & Vancouver Coastal Health. Vancouver, Canada.
Parkinsonism Relat Disord. 2014 Jan;20 Suppl 1:S180-3. doi: 10.1016/S1353-8020(13)70042-7.
Positron emission tomography (PET) is a powerful technique to quantitatively assess brain function in vivo. In Parkinson's disease (PD), PET can assist in the identification of dopamine deficiency, the characterization of dopamine and other neurotransmitter receptors and transporters, serve as a biomarker and provide insights into motor and non-motor complications of PD. PET can also shed light on mechanisms that underlie disease, such as aberrant protein deposition and neuroinflammation. Emerging developments in multimodal imaging offer the opportunity to study multiple questions concurrently and offer great promise for the future.
正电子发射断层扫描（PET）是一种强大的技术，可定量评估体内大脑功能。在帕金森病（PD）中，PET 可协助识别多巴胺缺乏，描述多巴胺和其他神经递质受体和转运体，作为生物标志物，并深入了解 PD 的运动和非运动并发症。PET 还可以揭示疾病背后的机制，如异常蛋白沉积和神经炎症。多模态成像的新兴发展为同时研究多个问题提供了机会，并为未来带来了巨大的希望。
