Department of Medicine, University of California at Los Angeles, CA, USA.
Clin Immunol. 2013 Dec;149(3):530-3. doi: 10.1016/j.clim.2013.09.002. Epub 2013 Sep 12.
In systemic lupus erythematosus (SLE), the impairment in apoptosis can facilitate the initiation and maintenance of autoimmune responses to self antigens. Here we show that the adipocytokine leptin, which is abnormally elevated in SLE, promotes the survival and proliferation of autoreactive T-cells in mice with an autoreactive T-cell repertoire, including (NZB x NZW)F1 lupus-prone mice. This ability of leptin to promote lupus T-cell autoimmunity suggests the possibility of a therapeutic targeting of leptin in SLE.
在系统性红斑狼疮（SLE）中，凋亡的损伤可促进自身抗原的自身免疫反应的启动和维持。在这里，我们发现，脂肪细胞因子瘦素在 SLE 中异常升高，可促进具有自身反应性 T 细胞库的包括（NZB x NZW）F1 狼疮易感小鼠在内的自身反应性 T 细胞的存活和增殖。瘦素促进狼疮 T 细胞自身免疫的能力表明，在 SLE 中靶向瘦素治疗具有可能性。
