Urményi Turán P, Silva Rosane, Rondinelli Edson
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil,
Subcell Biochem. 2014;74:119-35. doi: 10.1007/978-94-007-7305-9_5.
Trypanosoma cruzi is the causal agent of Chagas' disease, a debilitating disorder affecting millions of people in several countries. A flagellated protozoan parasite, T. cruzi has a complex life cycle that involves infecting an insect and a mammalian host. During its life cycle, the parasite undergoes several kinds of stress, prominent among which is heat stress. To deal with this environmental challenge, molecular chaperones and proteases, also known as heat shock proteins (HSPs), are induced as part of the stress response. Several families of HSPs are synthesized by T. cruzi, including members of the major HSP classes such as HSP70, HSP90, HSP100, HSP40, chaperonins and small HSPs, and these proteins show conserved and unique features. In this review we describe these proteins and the corresponding gene expression patterns and discuss their relevance to the biology of the parasite.
克氏锥虫是恰加斯病的病原体，这种使人衰弱的疾病影响着几个国家的数百万人。克氏锥虫是一种有鞭毛的原生动物寄生虫，其生命周期复杂，涉及感染昆虫和哺乳动物宿主。在其生命周期中，寄生虫会经历多种应激，其中突出的是热应激。为应对这一环境挑战，分子伴侣和蛋白酶（也称为热休克蛋白（HSP））作为应激反应的一部分被诱导产生。克氏锥虫合成了几个热休克蛋白家族，包括主要热休克蛋白类别的成员，如HSP70、HSP90、HSP100、HSP40、伴侣蛋白和小热休克蛋白，这些蛋白质具有保守和独特的特征。在这篇综述中，我们描述了这些蛋白质及其相应的基因表达模式，并讨论了它们与寄生虫生物学的相关性。
