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女性月经周期排卵期周围阶段腹膜液中蛋白质的变化模式。

Patterns of changes in proteins in the peritoneal fluid of women during the periovulatory phase of the menstrual cycle.

作者信息

Bouckaert P X, Evers J L, Doesburg W H, Schellekens L A, Brombacher P H, Rolland R

出版信息

J Reprod Fertil. 1986 Jul;77(2):329-36. doi: 10.1530/jrf.0.0770329.

DOI:10.1530/jrf.0.0770329
PMID:2426448
Abstract

During a laparoscopy that was performed between Day -6 and Day +9 of the cycle as related to the day of the LH peak (Day 0), the peritoneal fluid of 100 healthy female volunteers of proven fertility was collected and analysed. Peritoneal fluid volume and concentrations of total protein, albumin, alpha 1-, alpha 2-, beta- and gamma-globulins, IgA, IgG, IgM, haptoglobulin, acid-alpha 1-glycoprotein, alpha 1-antitrypsin, alpha 2-macroglobulin, C3-, C4- and C-reactive protein were determined. The peritoneal fluid volume and the concentrations of most proteins analysed showed an increase during the post-ovulatory phase of the period investigated. The peritoneal fluid:serum ratio of each individual protein showed a significant inverse correlation with its molecular weight. This confirms the assumption that peritoneal fluid is mainly an exudation product, most probably of ovarian origin.

摘要

在与促黄体生成素峰值日(第0天)相关的月经周期第-6天至第+9天期间进行腹腔镜检查时,收集并分析了100名已证实具有生育能力的健康女性志愿者的腹腔液。测定了腹腔液体积以及总蛋白、白蛋白、α1-、α2-、β-和γ-球蛋白、IgA、IgG、IgM、触珠蛋白、酸性α1-糖蛋白、α1-抗胰蛋白酶、α2-巨球蛋白、C3、C4和C反应蛋白的浓度。在所研究时期的排卵后期,腹腔液体积和大多数分析蛋白的浓度均有所增加。每种蛋白质的腹腔液与血清的比率与其分子量呈显著负相关。这证实了腹腔液主要是一种渗出产物、很可能源自卵巢的假设。

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