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两种小麦过敏表型中特定 IgE 抗体与小麦成分过敏原的比较。

Comparison of specific IgE antibodies to wheat component allergens in two phenotypes of wheat allergy.

机构信息

Department of Internal Medicine, Dong-A University School of Medicine, Busan, Korea.

出版信息

J Korean Med Sci. 2013 Nov;28(11):1697-9. doi: 10.3346/jkms.2013.28.11.1697. Epub 2013 Oct 31.

DOI:10.3346/jkms.2013.28.11.1697
PMID:24265539
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3835518/
Abstract

Specific IgE to gliadin was proposed as a marker for wheat dependent exercise induced anaphylaxis, while Tri a 14 was found to induce IgE response in baker's asthma. We evaluated whether these components could be used for discriminating phenotypes of wheat allergy. Twenty-nine patients who were wheat-induced anaphylaxis and/or urticaria (n=21, group I) and baker's asthma (n=8, group II) were enrolled. The prevalence of serum specific IgE to Tri a 14 was higher in group II (25%) than in group I (4.8%), while the serum specific IgE to gliadin was significantly higher in group I (70%) than in group II (12.5%). The cutoff value for predicting the baker's asthma using the ratio of serum specific IgE to Tri a 14 to gliadin was 742.8 optical density×1,000/(kU/L) with high sensitivity and specificity. These findings suggest that Tri a 14/gliadin may be a potential marker for predicting baker's asthma.

摘要

针对麸质的特异性 IgE 被提议作为小麦依赖运动诱发过敏反应的标志物，而 Tri a 14 被发现可引起烘焙师哮喘的 IgE 反应。我们评估了这些成分是否可用于区分小麦过敏的表型。招募了 29 例小麦诱导的过敏反应和/或荨麻疹患者（n=21，I 组）和烘焙师哮喘患者（n=8，II 组）。II 组（25%）中血清特异性 IgE 对 Tri a 14 的阳性率高于 I 组（4.8%），而 I 组（70%）中血清特异性 IgE 对 gliadin 的阳性率显著高于 II 组（12.5%）。使用血清特异性 IgE 对 Tri a 14 与 gliadin 的比值预测烘焙师哮喘的截断值为 742.8 光密度×1,000/(kU/L)，具有较高的灵敏度和特异性。这些发现表明 Tri a 14/gliadin 可能是预测烘焙师哮喘的潜在标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5bf/3835518/6626ef630fe0/jkms-28-1697-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5bf/3835518/6626ef630fe0/jkms-28-1697-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5bf/3835518/6626ef630fe0/jkms-28-1697-g001.jpg

相似文献

[1]
Comparison of specific IgE antibodies to wheat component allergens in two phenotypes of wheat allergy.

J Korean Med Sci. 2013-10-31

[2]
Allergenic Biomarkers in the Molecular Diagnosis of IgE-Mediated Wheat Allergy.

Int J Mol Sci. 2024-7-27

[3]
Anaphylaxis to wheat flour-derived foodstuffs and the lipid transfer protein syndrome: a potential role of wheat lipid transfer protein Tri a 14.

Int Arch Allergy Immunol. 2009-12-16

[4]
Identification of wheat gliadins as an allergen family related to baker's asthma.

J Allergy Clin Immunol. 2008-3

[5]
Diagnostic value of the serum-specific IgE ratio of ω-5 gliadin to wheat in adult patients with wheat-induced anaphylaxis.

Int Arch Allergy Immunol. 2011-10-5

[6]
Component-resolved diagnosis of baker's allergy based on specific IgE to recombinant wheat flour proteins.

J Allergy Clin Immunol. 2015-1-7

[7]
Immunoglobulin E-reactivity of wheat-allergic subjects (baker's asthma, food allergy, wheat-dependent, exercise-induced anaphylaxis) to wheat protein fractions with different solubility and digestibility.

Mol Nutr Food Res. 2004-10

[8]
Recombinant high molecular weight-glutenin subunit-specific IgE detection is useful in identifying wheat-dependent exercise-induced anaphylaxis complementary to recombinant omega-5 gliadin-specific IgE test.

Clin Exp Allergy. 2012-8

[9]
Thaumatin-like protein and baker's respiratory allergy.

Ann Allergy Asthma Immunol. 2010-2

[10]
The clinical spectrum of omega-5-gliadin allergy.

Intern Med J. 2016-6

引用本文的文献

[1]
Very low prevalence of IgE mediated wheat allergy and high levels of cross-sensitisation between grass and wheat in a UK birth cohort.

Clin Transl Allergy. 2016-6-22

本文引用的文献

[1]
Diagnostic value of the serum-specific IgE ratio of ω-5 gliadin to wheat in adult patients with wheat-induced anaphylaxis.

Int Arch Allergy Immunol. 2011-10-5

[2]
Wheat allergens associated with Baker's asthma.

J Investig Allergol Clin Immunol. 2011

[3]
Food allergy: recent advances in pathophysiology and treatment.

Allergy Asthma Immunol Res. 2009-9-25

[4]
Recombinant lipid transfer protein Tri a 14: a novel heat and proteolytic resistant tool for the diagnosis of baker's asthma.

Clin Exp Allergy. 2009-8

[5]
The prevalence of plant food allergies: a systematic review.

J Allergy Clin Immunol. 2008-5

[6]
The CREATE project: development of certified reference materials for allergenic products and validation of methods for their quantification.

Allergy. 2008-3

[7]
Sensitivity and specificity of recombinant omega-5 gliadin-specific IgE measurement for the diagnosis of wheat-dependent exercise-induced anaphylaxis.

Allergy. 2008-2

[8]
Identification of wheat gliadins as an allergen family related to baker's asthma.

J Allergy Clin Immunol. 2008-3

[9]
Wheat lipid transfer protein is a major allergen associated with baker's asthma.

J Allergy Clin Immunol. 2007-11

[10]
Wheat IgE-mediated food allergy in European patients: alpha-amylase inhibitors, lipid transfer proteins and low-molecular-weight glutenins. Allergenic molecules recognized by double-blind, placebo-controlled food challenge.

Int Arch Allergy Immunol. 2007

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