Atalay Talha, Cakir Murat, Tekin Ahmet, Kucukkartallar Tevfik, Kargin Suleyman, Kartal Adil, Kaynak Adnan
Department of General Surgery, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey.
J Korean Surg Soc. 2013 Nov;85(5):219-24. doi: 10.4174/jkss.2013.85.5.219. Epub 2013 Oct 25.
Hepatopulmonary syndrome is an arterial oxygenation disorder brought about by advanced liver failure and pulmonary vascular dilatations. The reason why hypoxia develops in hepatopulmonary syndrome depends on the broadening of perialveolar capillary veins. Our study aims to investigate the effects of Flavanoid on hepatopulmonary syndrome through its inhibition of nitric oxide.
Three groups, each having 8 rats, were formed within the scope of our study. Group I (the control group) only received laparatomy, group II received choledoch ligation, and group III was administered Flavanoid (90% flavonoid diosmin, 10% flavonoid hesperidin) following choledoch ligation. The rats were administered Flavanoid at week two following choledoch ligation. The rats' livers and lungs were examined histopathologically following a five-week follow-up and the perialveolar vein diameters were measured. Arterial blood gases and biochemical parameters were evaluated.
It was seen that fibrosis and oxidative damage in the liver with obstructive jaundice as well as hypoxia with pulmonary perialveolar vein sizes were significantly lower than the other group with cirrhosis formed through the administration of Flavanoid.
We have concluded that Flavanoid administration might be useful in the treatment of hypoxia in hepatopulmonary syndrome and the delay of cirrhosis contraction.
肝肺综合征是一种由晚期肝衰竭和肺血管扩张引起的动脉氧合障碍。肝肺综合征中缺氧发生的原因取决于肺泡周围毛细血管静脉的扩张。我们的研究旨在通过抑制一氧化氮来研究类黄酮对肝肺综合征的影响。
在我们的研究范围内，将大鼠分为三组，每组8只。第一组（对照组）仅接受剖腹手术，第二组接受胆总管结扎，第三组在胆总管结扎后给予类黄酮（90%地奥司明类黄酮，10%橙皮苷类黄酮）。在胆总管结扎后第2周给大鼠施用类黄酮。经过5周的随访后，对大鼠的肝脏和肺进行组织病理学检查，并测量肺泡周围静脉直径。评估动脉血气和生化参数。
可见，与通过施用类黄酮形成肝硬化的另一组相比，阻塞性黄疸大鼠肝脏中的纤维化和氧化损伤以及肺肺泡周围静脉大小导致的缺氧明显更低。
我们得出结论，施用类黄酮可能有助于治疗肝肺综合征中的缺氧和延缓肝硬化的收缩。
