Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; John C. McDonald Regional Transplant Center, Willis-Knighton Health System, Shreveport, LA; Division of Nephrology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA.
Am J Transplant. 2013 Dec;13(12):3210-4. doi: 10.1111/ajt.12488. Epub 2013 Nov 13.
The aim of this cross-sectional study was to assess the health status and quality of life (QOL) of paid unrelated versus related living kidney donors postdonation at Shiraz Transplant Center in Iran. We invited all donors (n = 580, 347 paid unrelated, 233 related) who underwent donor nephrectomy at our center from 2004 to 2010 to participate in a health survey and physical examination. Of 580 donors, 144 consented to participate; participation of paid unrelated donors was significantly lower than related (52/347 vs. 92/233; p < 0.001). Participants underwent a complete physical examination, QOL assessment (using a 36-item short form health survey [SF-36] questionnaire) and laboratory work-up. The paid unrelated donors compared with related donors were younger (34.2 ± 7.2 vs. 40.7 ± 9.7 years, p < 0.001), had shorter time since donation (2.9 ± 1.6 vs. 3.8 ± 2 years, p = 0.004), had higher estimated GFR (72.6 ± 22 vs. 63.8 ± 15.3 mL/min/1.73 m(2), p = 0.006) and had a higher percentage of patients with microalbuminuria (35% vs. 0%, p < 0.001). Additionally, general health and social functioning scores among paid unrelated donors were significantly lower (p < 0.001 and p = 0.02, respectively) than related donors. Other SF-36 scores, although lower in paid unrelated donors, did not reach statistical significance. Iranian paid unrelated donors have lower QOL and higher incidence of microalbuminuria compared with related donors.
本横断面研究旨在评估伊朗 Shiraz 移植中心的有偿非亲属与亲属活体供肾者捐赠后的健康状况和生活质量 (QOL)。我们邀请了所有在我们中心接受供肾切除术的供者（n=580，347 名有偿非亲属，233 名亲属）参加健康调查和体检。在 580 名供者中，有 144 名同意参加；有偿非亲属供者的参与率明显低于亲属（52/347 与 92/233；p<0.001）。参与者接受了全面体检、QOL 评估（使用 36 项简短健康调查问卷 [SF-36]）和实验室检查。与亲属供者相比，有偿非亲属供者更年轻（34.2±7.2 与 40.7±9.7 岁，p<0.001），捐赠后时间更短（2.9±1.6 与 3.8±2 年，p=0.004），估算肾小球滤过率更高（72.6±22 与 63.8±15.3 mL/min/1.73 m2，p=0.006），且微量白蛋白尿患者比例更高（35%与 0%，p<0.001）。此外，有偿非亲属供者的一般健康和社会功能评分明显较低（p<0.001 和 p=0.02）。虽然有偿非亲属供者的其他 SF-36 评分较低，但未达到统计学意义。与亲属供者相比，伊朗有偿非亲属供者的 QOL 较低，且微量白蛋白尿的发生率较高。
