Advanced Lung Disease and Transplant Program, Department of Medicine, Inova Fairfax Hospital, 3300 Gallows Road, Falls Church, VA 22042, USA.
Clin Chest Med. 2013 Dec;34(4):695-705. doi: 10.1016/j.ccm.2013.08.004. Epub 2013 Oct 17.
Pulmonary hypertension may complicate the course of patients with many forms of advanced lung disease. The cause is likely multifactorial with pathogenic pathways both common and unique to the specific disease entities. The occurrence of pulmonary hypertension is associated with worse outcomes, but whether this is an adaptive or maladaptive phenomenon remains unknown. The treatment of pulmonary hypertension with vasoactive medications in lung disease remains unproved. Specific disease phenotypes that might benefit, and those in which such therapies might be deleterious, remain to be determined.
肺动脉高压可能使多种晚期肺部疾病患者的病情复杂化。其病因可能是多因素的，特定疾病实体的共同和独特的发病途径都可能致病。肺动脉高压的发生与预后更差相关，但这是一种适应性还是失代偿性现象仍不清楚。在肺部疾病中使用血管活性药物治疗肺动脉高压尚未得到证实。哪些特定的疾病表型可能受益，以及哪些疾病表型可能有害，仍有待确定。
