长春新碱、博来霉素和甲氨蝶呤新辅助化疗联合放疗治疗晚期头颈部鳞状细胞癌

Neoadjuvant chemotherapy with vincristine, bleomycin and methotrexate combined with radiotherapy in advanced head and neck squamous cell carcinoma.

作者信息

Amichetti M, Bolner A, Busana L, Fellin G, Pani G, Piffer S, Valdagni R, Ambrosini G

出版信息

Tumori. 1986 Jun 30;72(3):301-6. doi: 10.1177/030089168607200311.

DOI:10.1177/030089168607200311

Abstract

From September 1980 to August 1981, 25 patients with advanced head and neck squamous cell carcinoma were treated at the Centro Oncologico, Trento, by a chemo-radiotherapeutic combination. The treatment protocol consisted of 4-6 courses of VBM (vincristine, bleomycin and methotrexate) followed by conventional radiotherapy (65 Gy). Only to VBM responders (15 patients) were administered 10 cycles of vincristine-methotrexate. At the end of induction chemotherapy an overall response of 60% (12% complete, 48% partial) was obtained. At the end of radiotherapy the responses were 52.5% complete and 35.5% partial, for an overall response of 88%. The overall survival at 60 months was 8%. This combined approach, in spite of the satisfactory immediate local response rate, does not offer advantages for survival in comparison to conventional treatment modalities.

摘要

1980年9月至1981年8月，25例晚期头颈部鳞状细胞癌患者在特伦托肿瘤中心接受了化疗与放疗联合治疗。治疗方案包括4 - 6个疗程的VBM（长春新碱、博来霉素和甲氨蝶呤），随后进行常规放疗（65 Gy）。仅对VBM治疗有反应的患者（15例）给予10个疗程的长春新碱 - 甲氨蝶呤治疗。诱导化疗结束时，总缓解率为60%（完全缓解12%，部分缓解48%）。放疗结束时，完全缓解率为52.5%，部分缓解率为35.5%，总缓解率为88%。60个月时的总生存率为8%。尽管这种联合治疗方法的近期局部缓解率令人满意，但与传统治疗方式相比，在生存方面并无优势。