Elloumi F, Ben Amor M, Ghorbel L, Mnif H, Boudawara T, Ghorbel A M, Frikha M, Daoud J
Service de radiothérapie carcinologique, CHU Habib Bourguiba, Sfax, Tunisie.
Cancer Radiother. 2013 Dec;17(8):768-70. doi: 10.1016/j.canrad.2013.09.004. Epub 2013 Nov 20.
Metastasis to the central nervous system, either through a hematogenous route or through the cerebrospinal fluid, is extremely rare in nasopharynx cancer. We aim to expose clinical aspects, therapeutic features and prognosis of nasopharyngeal carcinoma with brain metastases. We retrospectively reviewed the medical history of about 420 patients with nasopharyngeal carcinoma treated during 17 years at the university hospital of Sfax (Tunisia). Among them, three patients had brain metastasis. We excluded patients with direct extension to the brain. Tumours of the nasopharynx were locally advanced. The first patient had brain metastases at the initial diagnosis. The two other patients had brain metastases at 10 and 16 months during the follow-up. Ocular signs were the symptoms. Lesions were unique in two patients. Synchronous bone metastases were recorded in the three cases. All patients had whole brain radiation therapy and palliative chemotherapy. All patients had a progression of the disease and died. Brain metastases in nasopharynx cancer represent a rare event. Prognosis is poor, depending on age, surgical excision and synchronous metastases. Survival does not exceed 6 months.
鼻咽癌通过血行途径或脑脊液转移至中枢神经系统极为罕见。我们旨在揭示鼻咽癌脑转移的临床特征、治疗特点及预后情况。我们回顾性分析了突尼斯斯法克斯大学医院17年间收治的约420例鼻咽癌患者的病史。其中，3例发生脑转移。我们排除了肿瘤直接侵犯脑部的患者。鼻咽癌均为局部晚期。首例患者初诊时即有脑转移。另外2例患者在随访期间分别于10个月和16个月时出现脑转移。眼部症状为主要表现。2例患者的病灶为单发。3例均有同步骨转移。所有患者均接受了全脑放射治疗和姑息化疗。所有患者病情均进展并死亡。鼻咽癌脑转移实属罕见。预后较差，取决于年龄、手术切除情况及同步转移情况。生存期不超过6个月。
