Department of General Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Department of General Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
FEBS Lett. 2014 Jan 3;588(1):99-104. doi: 10.1016/j.febslet.2013.11.014. Epub 2013 Nov 20.
MicroRNAs (miRNAs) have recently emerged as regulators of metastasis. We provide insight into the behavior of miR-221 in colorectal cancer (CRC) metastasis by showing that miR-221 is significantly upregulated in metastatic CRC cell lines and tissues. miR-221 overexpression enhances, whereas miR-221 depletion reduces CRC cell migration and invasion in vitro and metastasis in vivo. We identify RECK as a direct target of miR-221, reveal its expression to be inversely correlated with miR-221 in CRC samples and show that its re-introduction reverses miR-221-induced CRC invasiveness. Collectively, miR-221 is an oncogenic miRNA which may regulate CRC migration and invasion through targeting RECK.
MicroRNAs (miRNAs) 最近被发现是转移的调控因子。我们通过显示 miR-221 在转移性结直肠癌 (CRC) 细胞系和组织中显著上调，深入了解了 miR-221 在 CRC 转移中的行为。miR-221 的过表达增强，而 miR-221 的耗竭减少 CRC 细胞在体外的迁移和侵袭以及体内的转移。我们确定 RECK 是 miR-221 的直接靶标，揭示其表达与 CRC 样本中的 miR-221 呈负相关，并表明其重新引入可逆转 miR-221 诱导的 CRC 侵袭性。总之，miR-221 是一种致癌 miRNA，可能通过靶向 RECK 来调节 CRC 的迁移和侵袭。
