Malone D G, Irani A M, Schwartz L B, Barrett K E, Metcalfe D D
Arthritis Rheum. 1986 Aug;29(8):956-63. doi: 10.1002/art.1780290803.
Thirty-five synovial fluid (SF) specimens were examined for the presence of mast cells and for their histamine content. Mast cells were seen in SF cells from 27 of 35 fluids, and histamine was measurable in 19 of 34. There was a strong correlation between mast cell number and histamine content. No consistent relationship was found between either the mast cell number or histamine level and the patients' diagnoses, except that the 2 patients with systemic mastocytosis had markedly elevated values for both SF mast cell number and histamine content. SF mast cells from one of the mastocytosis patients were studied for histamine release; significant amounts of histamine were released upon exposure to anti-human IgE, but not compound 48/80. Thus, mast cells similar to those present in connective tissue are frequently present in SF in numbers which correlate with SF histamine levels. These mast cells contain active proteases and are capable of degranulation. Mast cells were consistently present in large numbers in the SF of patients with systemic mastocytosis, but their numbers were highly variable in fluids of patients with other diseases.
对35份滑液（SF）标本进行了肥大细胞检测及其组胺含量测定。在35份滑液中的27份标本的滑液细胞中发现了肥大细胞，在34份标本中的19份可检测到组胺。肥大细胞数量与组胺含量之间存在强相关性。除了2例系统性肥大细胞增多症患者的滑液肥大细胞数量和组胺含量均显著升高外，未发现肥大细胞数量或组胺水平与患者诊断之间存在一致关系。对其中1例肥大细胞增多症患者的滑液肥大细胞进行了组胺释放研究；暴露于抗人IgE时可释放大量组胺，但暴露于化合物48/80时则不会。因此，与结缔组织中存在的肥大细胞相似的肥大细胞经常存在于滑液中，其数量与滑液组胺水平相关。这些肥大细胞含有活性蛋白酶，能够脱颗粒。系统性肥大细胞增多症患者的滑液中始终大量存在肥大细胞，但在其他疾病患者的滑液中其数量变化很大。
