蛋氨酸对易激惹性蛋氨酸亚砜亚胺在大鼠体内摄取、分布和结合的影响。
The effect of methionine on the uptake, distribution, and binding of the convulsant methionine sulfoximine in the rat.
机构信息
Laboratory of Neurochemistry Mental Health Research Institute, University of Michigan Medical Center, 48014, Ann Arbor, Michigan.
出版信息
Neurochem Res. 1976 Feb;1(1):53-63. doi: 10.1007/BF00965631.
The effect of methionine on the uptake, distribution, and binding of the convulsant methionine sulfoximine (MSO) in 7 rat brain regions, the spinal cord, the liver, and the kidney was investigated. The administration of methionine decreased the uptake of MSO in all brain regions. The uptake of MSO by and its distribution in the nervous tissue was uniform and failed to result in any preferential accumulation of the drug. Methionine decreased the amount of MSO bound to cerebral structures and to the spinal cord. MSO bound to the spinal cord was less susceptible to release by Triton X-100 than was brain-bound MSO.
本研究旨在探讨蛋氨酸对致惊厥剂蛋氨酸亚砜（MSO）在 7 个大鼠脑区、脊髓、肝脏和肾脏中摄取、分布和结合的影响。结果表明，蛋氨酸的给药降低了所有脑区中 MSO 的摄取。MSO 在神经组织中的摄取和分布均匀，未能导致药物的任何优先积累。蛋氨酸减少了 MSO 与脑结构和脊髓的结合量。与脑结合的 MSO 相比，脊髓结合的 MSO 对 Triton X-100 的释放更不易。
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