Azimova Sh S, Normatov K, Men'shikov M Iu
Biull Eksp Biol Med. 1986 Aug;102(8):226-8.
The effect of thyroid hormone receptors isolated from normal and malignant cells on the induction of Ca2+ transport to platelets was studied. It is established that the receptor isolated from malignant cells by thyroxin (T4) or triiodothyronine (T3) stimulates (three-fold) the induction of Ca2+ transport to platelets. The effect is blocked by verapamil, which is the inhibitor of Ca2+ channels in plasma membranes. It is shown that neither the receptor of cancer cells, nor hormones (T3 or T4) influence the transport of Ca2+ to platelets without preliminary complexing. The hormone-receptor complex failed to affect the concentration of "cytoplasmic" Ca2+ in platelets analogous experimental conditions. It is suggested that the increased Ca2+ content in cancer cells can be partially attributed to the ability of thyroid hormone receptor of cancer cells to induce Ca2+ transport across the plasma membrane.
研究了从正常细胞和恶性细胞中分离出的甲状腺激素受体对诱导钙离子转运至血小板的作用。已证实，通过甲状腺素（T4）或三碘甲状腺原氨酸（T3）从恶性细胞中分离出的受体可刺激（三倍）钙离子转运至血小板。维拉帕米可阻断该作用，维拉帕米是质膜中钙离子通道的抑制剂。结果表明，癌细胞受体和激素（T3或T4）在未预先形成复合物的情况下均不影响钙离子向血小板的转运。在类似实验条件下，激素 - 受体复合物未能影响血小板中“细胞质”钙离子的浓度。提示癌细胞中钙离子含量增加可能部分归因于癌细胞甲状腺激素受体诱导钙离子跨质膜转运的能力。
