S-氧化在大鼠肝脏硫杂芳烃代谢中的主要作用。
The predominant role of S-oxidation in rat liver metabolism of thiaarenes.
作者信息
Jacob J, Schmoldt A, Grimmer G
出版信息
Cancer Lett. 1986 Jul;32(1):107-16. doi: 10.1016/0304-3835(86)90045-5.
PMID:2427191
Abstract
Thiaarenes are metabolized by liver microsomes of untreated rats predominantly to sulfones and sulfoxides. After pretreatment of rats with monooxygenase inducers, ring oxidation of thiaarenes is also observed. In case of benzo[b]naphtho[2,3-d]thiophene the formation of a p-quinone takes place. Rat liver microsomal metabolism of the thiaarenes tested as substrates did not resemble that of the polycyclic aromatic hydrocarbon (PAH) isosters at all.
摘要
硫杂芳烃主要被未经处理的大鼠肝脏微粒体代谢为砜和亚砜。在用单加氧酶诱导剂对大鼠进行预处理后，也观察到了硫杂芳烃的环氧化反应。就苯并[b]萘并[2,3-d]噻吩而言，会形成对苯醌。作为底物测试的硫杂芳烃的大鼠肝脏微粒体代谢与多环芳烃（PAH）等电子体的代谢完全不同。
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