探索和利用 microRNAs 在肿瘤发病机制中的基本作用。
Exploring and exploiting the fundamental role of microRNAs in tumor pathogenesis.
机构信息
Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, People's Republic of China.
出版信息
Onco Targets Ther. 2013 Nov 18;6:1675-84. doi: 10.2147/OTT.S52730. eCollection 2013.
Abstract
miRNAs (miRs) are short RNA molecules that are involved in the posttranscriptional regulation of mRNA. The roles of miRs in tumor pathogenesis have only recently become a focus of research. It is becoming increasingly clear that miRs are important regulators of apoptosis, proliferation, invasion, and metastasis in cancer cells during cancer genesis and progression, furthering our understanding of cancer. In the present review, we summarize and evaluate the recent advances in our understanding of the characteristics of miRs as well as their regulated functions in cancer stem cells (CSCs), the epithelial-mesenchymal transition (EMT), and the tumor microenvironment (TM), describing their roles in tumor pathogenesis and their possible use as new therapeutic targets and biomarkers.
摘要
miRNAs (miRs) 是参与 mRNA 转录后调控的短 RNA 分子。miRs 在肿瘤发病机制中的作用最近才成为研究的焦点。越来越明显的是，miRs 是肿瘤发生和进展过程中癌细胞凋亡、增殖、侵袭和转移的重要调节剂，进一步加深了我们对癌症的理解。在本综述中，我们总结和评估了最近对 miRs 特征及其在癌症干细胞 (CSCs)、上皮-间充质转化 (EMT) 和肿瘤微环境 (TM) 中调控功能的理解方面的进展，描述了它们在肿瘤发病机制中的作用及其作为新的治疗靶点和生物标志物的可能用途。
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1
Downregulation of miR-29 contributes to cisplatin resistance of ovarian cancer cells.
Int J Cancer. 2014 Feb 1;134(3):542-51. doi: 10.1002/ijc.28399. Epub 2013 Aug 28.
2
MicroRNA-145 downregulation associates with advanced tumor progression and poor prognosis in patients suffering osteosarcoma.
Onco Targets Ther. 2013 Jul 8;6:833-8. doi: 10.2147/OTT.S40080. Print 2013.
3
MicroRNA-19a-3p inhibits breast cancer progression and metastasis by inducing macrophage polarization through downregulated expression of Fra-1 proto-oncogene.
Oncogene. 2014 Jun 5;33(23):3014-23. doi: 10.1038/onc.2013.258. Epub 2013 Jul 8.
4
Hypoxia induces the overexpression of microRNA-21 in pancreatic cancer cells.
J Surg Res. 2013 Oct;184(2):855-60. doi: 10.1016/j.jss.2013.04.061. Epub 2013 May 18.
5
EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2.
Nature. 2013 May 16;497(7449):383-7. doi: 10.1038/nature12080. Epub 2013 May 1.
6
MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer.
Immunity. 2013 Apr 18;38(4):742-53. doi: 10.1016/j.immuni.2012.12.006.
7
MicroRNA-141 is downregulated in human renal cell carcinoma and regulates cell survival by targeting CDC25B.
Onco Targets Ther. 2013 Apr 10;6:349-54. doi: 10.2147/OTT.S41343. Print 2013.
8
MicroRNAs activate natural killer cells through Toll-like receptor signaling.
Blood. 2013 Jun 6;121(23):4663-71. doi: 10.1182/blood-2012-07-441360. Epub 2013 Apr 11.
9
miRNA-200c increases the sensitivity of breast cancer cells to doxorubicin through the suppression of E-cadherin-mediated PTEN/Akt signaling.
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10
MicroRNA-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer.
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