一个用于描述低剂量时增加的放射敏感性与2格雷剂量下存活率之间关系的对数公式。
A Logarithmic Formula to Describe the Relationship between the Increased Radiosensitivity at Low Doses and the Survival at 2 Gray.
作者信息
Azooz Faika A, Hashim Suzan K
机构信息
Department of Physics, College of Education, University of Mosul, Mosul, Ninevah, Iraq.
出版信息
Sultan Qaboos Univ Med J. 2013 Nov;13(4):560-6. doi: 10.12816/0003316. Epub 2013 Nov 8.
Abstract
OBJECTIVES
Intrinsic radiosensitivity at doses used in radiotherapy is linked to hypersensitivity (HRS) and increased radio resistance (IRR) at low doses. The aim of this study was to explore this relationship.
METHODS
Survival curves for 18 human tumour cell lines were analysed, using two models to fit the data points in order to extract the necessary parameters relevant for this study.
RESULTS
The IRR ratio αs/αr versus the survival at 2 gray (Gy) can be described by a logarithmic relation which leads to a series of straight lines.
CONCLUSION
The relationship obtained implies that there is a direct link between HRS/IRR and survival at clinically relevant doses of 2 Gy.
摘要
目的
放射治疗中使用的剂量下的内在放射敏感性与低剂量时的超敏反应（HRS）和放射抗性增加（IRR）相关。本研究的目的是探讨这种关系。
方法
分析了18种人类肿瘤细胞系的存活曲线，使用两种模型拟合数据点以提取本研究相关的必要参数。
结果
IRR比率αs/αr与2戈瑞（Gy）时的存活率之间的关系可用对数关系描述，这导致了一系列直线。
结论
所获得的关系表明，HRS/IRR与临床相关剂量2 Gy时的存活率之间存在直接联系。
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