[Combinations of bronchodilators in COPD therapy--"fashionable" or rule?].

Combinations of bronchodilators are becoming more and more common in COPD guidelines but also in the practitioner's hand. It starts from the complementary action of two classes of bronchodilators, inhaled anticholinergics and beta 2 adrenergics and have a dynamic evolution analysed in this article, starting with the new rules introduced by the GOLD guide until the possible changes in attitudes of the therapist in the moment when they will have them at their fingertips.