[Immunochemical approach to clinical cytology by demonstration of tumor markers using enzyme-labeled antibody technic].

Demonstration of tumor markers using the enzyme-labeled antibody technique was evaluated as an immunochemical approach to cytodiagnosis. AFP, CEA, CA 19-9, or CA 125 were stained in specimens of pleural effusion, ascites, cerebrospinal fluid, hepatopancreatic tumor, bone marrow and spuata. Malignant cells of the cases with elevated marker levels in the body fluid were mostly positively stained. And, interestingly enough, some of the malignant cases showed positively, while diagnosis by Papanicolaou's staining was not established for malignancy. It is suggested that immunochemical cytology by tumor marker staining would be useful for analyzing malignant cells and helpful in clinical cytology.