Department of Parasitology Mycology, Faculty of Medicine, Université des Sciences de la Santé, BP 4009 Libreville, Gabon.
Department of Parasitology Mycology, Faculty of Medicine, Université des Sciences de la Santé, BP 4009 Libreville, Gabon.
Acta Trop. 2014 Mar;131:11-5. doi: 10.1016/j.actatropica.2013.11.012. Epub 2013 Nov 23.
Mansonella (M.) perstans filariasis is widely found in Africa, including Gabon where Loa loa is also endemic. This study reports the total IgE titres according to different bioclinical forms of single or co-infection with L. loa and M. perstans in 138 patients and 20 healthy controls. The median parasite density was significantly higher in cases of loiasis. IgE titres were higher in patients with microscopic dual-infection and in the group of patients with occult loiasis plus M. perstans microfilaraemia (8425 [5292-20,679]KUI/L and 6304 [1045-10,326]KUI/L, respectively), compared to individuals with either microfilaraemic Loa loa (3368 [1414-7074]KUI/L) or Mansonella (4370 [1478-7334]KUI/L) single infections (p<0.01). IgE levels were positively correlated with M. perstans microfilaraemia (rho=0.27; p<0.01). Compared to single infections, dual M. perstans-L. loa infection induces very high total IgE titres. Studies correlating IgE titres and clinical symptoms are needed to confirm the involvement of this immunoglobulin in the pathological processes during filariasis.
曼氏线虫（Mansonella）丝虫病广泛存在于非洲，包括洛氏丝虫也流行的加蓬。本研究根据 138 例患者和 20 例健康对照者的单一或混合感染洛氏丝虫和曼氏线虫的不同临床生物形态，报告了总 IgE 滴度。微丝蚴密度在丝虫病病例中显著更高。在微观双重感染的患者和隐匿性丝虫病加曼氏线虫微丝蚴血症组中，IgE 滴度更高（分别为 8425[5292-20679]KU/L 和 6304[1045-10326]KU/L），与微丝蚴血症洛氏丝虫（3368[1414-7074]KU/L）或曼氏线虫（4370[1478-7334]KU/L）单一感染的个体相比（p<0.01）。IgE 水平与曼氏线虫微丝蚴血症呈正相关（rho=0.27；p<0.01）。与单一感染相比，双重曼氏线虫-洛氏丝虫感染会引起非常高的总 IgE 滴度。需要进行关联 IgE 滴度和临床症状的研究，以确认这种免疫球蛋白在丝虫病病理过程中的作用。
