Department of Psychiatry, Institute of Clinical Medicine, University of Oulu, Oulu, Finland.
Neuropsychobiology. 2013;68(4):238-42. doi: 10.1159/000355300. Epub 2013 Nov 21.
Season of birth is associated with several psychiatric disorders and suicidal behavior. We explored the association between the season of birth and suicide among schizophrenic and psychotic suicide victims.
The study sample consisted of all suicides in the province of Oulu in Northern Finland from 1989 to 2010. Causes of death were extracted from death certificates, and psychiatric diagnoses associated with the hospital treatments were obtained from the Finnish Hospital Discharge Register. The seasons were defined as follows: winter (from November to January), spring (from February to April), summer (from May to July), and autumn (from August to October). Suicide victims (n = 1,902) were categorized as having either schizophrenia (n = 228) or psychosis other than schizophrenia (n = 240). Suicide victims without any hospital-treated mental disorder (n = 1,434) were used as a comparison group.
The distribution of births among suicide victims with schizophrenia differed statistically significantly from that observed in the general population, with a peak in summer (OR 1.2, 95% CI 1.0-1.5).
Birth during summer may predispose schizophrenic persons to suicide. The putative roles of serotonin, dopamine, and vitamin D status in the season of birth of psychotic suicide victims are discussed.
出生季节与多种精神疾病和自杀行为有关。我们探讨了出生季节与精神分裂症和精神病自杀者自杀之间的关系。
研究样本包括芬兰北部奥卢省 1989 年至 2010 年期间的所有自杀者。死因从死亡证明中提取，与医院治疗相关的精神科诊断从芬兰住院登记处获得。季节定义如下：冬季（11 月至 1 月）、春季（2 月至 4 月）、夏季（5 月至 7 月）和秋季（8 月至 10 月）。将自杀者（n=1902）分为精神分裂症（n=228）或非精神分裂症精神病（n=240）。没有任何医院治疗精神障碍的自杀者（n=1434）作为对照组。
精神分裂症自杀者的出生分布与一般人群相比存在统计学显著差异，夏季出生的比例较高（OR 1.2，95%CI 1.0-1.5）。
夏季出生可能使精神分裂症患者更容易自杀。讨论了血清素、多巴胺和维生素 D 状态在精神病自杀者出生季节中的作用。
