1] Centre for Cancer Biology, SA Pathology, Adelaide, South Australia, Australia [2] School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, South Australia, Australia [3] School of Medicine, University of Adelaide, Adelaide, South Australia, Australia.
Kidney Int. 2013 Dec;84(6):1065-7. doi: 10.1038/ki.2013.306.
Recurring peritonitis reduces the effectiveness of peritoneal dialysis by increasing fibrosis and angiogenesis, ultimately causing ultrafiltration failure (UFF). Identifying the processes underlying UFF will provide new hope for patients with chronic kidney disease. Catar and colleagues demonstrate that transforming growth factor-β, tumor necrosis factor-α, and interleukin-1 synergize to significantly increase the production and release of vascular endothelial growth factor by mesothelial cells, which, if untreated, will promote peritoneal angiogenesis, leading to UFF.
反复发作的腹膜炎通过增加纤维化和血管生成来降低腹膜透析的效果，最终导致超滤衰竭（UFF）。确定 UFF 的潜在过程将为慢性肾脏病患者带来新的希望。Catar 及其同事证明，转化生长因子-β、肿瘤坏死因子-α 和白细胞介素-1 协同作用，可显著增加间皮细胞产生和释放血管内皮生长因子，如果不加以治疗，这将促进腹膜血管生成，导致 UFF。
