Papapetrou P D, Nicopoulou S C
Acta Endocrinol (Copenh). 1986 Jul;112(3):415-22. doi: 10.1530/acta.0.1120415.
Immunoreactive human Chorionic Gonadotropin (hCG), its subunits and hCG beta-core fragment were analyzed, using Sephadex G-100 chromatography, in urine and tumour extracts from four patients with cancer. These patients were selected for investigation because they were excreting proportionally large amounts of the hCG beta-core fragment in their urine. Although 30-85% of the total immunoreactive urinary hCG was hCG beta fragment, traces of the fragment (2% of total hCG) were found in only two of the tumours and none in the other two. The predominant molecular form of hCG in the tumours was intact free beta-subunit of hCG. The conclusion is that the hCG beta-core fragment found in the urine of some patients with cancer is not a secretion product of the tumours. This fragment is very likely a peripheral degradation product of the free beta-subunit of hCG which is secreted by the tumours.
采用葡聚糖凝胶G - 100柱色谱法，对4例癌症患者尿液和肿瘤提取物中的免疫反应性人绒毛膜促性腺激素（hCG）、其亚基及hCGβ核心片段进行了分析。选择这些患者进行研究是因为他们尿液中排出的hCGβ核心片段比例较大。尽管尿液中免疫反应性hCG总量的30 - 85%为hCGβ片段，但仅在其中2例肿瘤中发现了微量该片段（占总hCG的2%），另外2例肿瘤中未发现。肿瘤中hCG的主要分子形式是完整的游离hCGβ亚基。结论是，部分癌症患者尿液中发现的hCGβ核心片段并非肿瘤的分泌产物。该片段很可能是肿瘤分泌的游离hCGβ亚基的外周降解产物。
