Department of Endocrinology and Metabolism, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark.
Eur J Endocrinol. 2013 Dec 27;170(2):341-8. doi: 10.1530/EJE-13-0708. Print 2014 Feb.
Thyroid hormones are essential for the normal development of the fetal brain, while hyperthyroidism in adults is associated with mood symptoms and reduced quality of life. In this study, we aimed to investigate the association and temporal relationship between hyperthyroidism and psychiatric morbidity.
Register-based nationwide cohort study.
Data on hyperthyroidism and psychiatric morbidity were obtained by record linkage of the Danish National Patient Registry and the Danish National Prescription Registry. A total of 2631 hyperthyroid individuals were identified and matched 1:4 with non-hyperthyroid controls and followed for a mean duration of 6 years (range 0-13). Logistic and Cox regression models were used to assess the risk of psychiatric morbidity before and after the diagnosis of hyperthyroidism respectively.
BEFORE THE DIAGNOSIS OF HYPERTHYROIDISM, SUCH INDIVIDUALS HAD AN INCREASED RISK OF BEING HOSPITALIZED WITH PSYCHIATRIC DIAGNOSES (ODDS RATIO (OR): 1.33; 95% CI: 0.98-1.80) and an increased risk of being treated with antipsychotics (OR: 1.17; 95% CI: 1.00-1.38), antidepressants (OR: 1.13; 95% CI: 1.01-1.27), or anxiolytics (OR: 1.28; 95% CI: 1.16-1.42). After the diagnosis of hyperthyroidism, there was a higher risk of being hospitalized with psychiatric diagnoses (hazard ratio (HR): 1.51; 95% CI: 1.11-2.05) and an increased risk of being treated with antipsychotics (HR: 1.46; 95% CI: 1.20-1.79), antidepressants (HR: 1.54; 95% CI: 1.36-1.74), or anxiolytics (HR: 1.47; 95% CI: 1.27-1.69).
Hyperthyroid individuals have an increased risk of being hospitalized with psychiatric diagnoses and being treated with antipsychotics, antidepressants, and anxiolytics, both before and after the diagnosis of hyperthyroidism.
甲状腺激素对胎儿大脑的正常发育至关重要，而成年人的甲状腺功能亢进与情绪症状和生活质量下降有关。本研究旨在探讨甲状腺功能亢进与精神疾病之间的关联和时间关系。
基于注册的全国队列研究。
通过丹麦国家患者登记处和丹麦国家处方登记处的记录链接获取甲状腺功能亢进和精神疾病的数据。共确定了 2631 例甲状腺功能亢进患者，并与非甲状腺功能亢进对照组 1:4 匹配，平均随访 6 年（0-13 年）。使用逻辑回归和 Cox 回归模型分别评估甲状腺功能亢进诊断前后发生精神疾病的风险。
在甲状腺功能亢进症诊断之前，此类患者住院治疗精神疾病的风险增加（优势比 (OR)：1.33；95%置信区间 (CI)：0.98-1.80），使用抗精神病药（OR：1.17；95%CI：1.00-1.38）、抗抑郁药（OR：1.13；95%CI：1.01-1.27）或抗焦虑药（OR：1.28；95%CI：1.16-1.42）的风险增加。甲状腺功能亢进症诊断后，住院治疗精神疾病的风险更高（风险比 (HR)：1.51；95%CI：1.11-2.05），使用抗精神病药（HR：1.46；95%CI：1.20-1.79）、抗抑郁药（HR：1.54；95%CI：1.36-1.74）或抗焦虑药（HR：1.47；95%CI：1.27-1.69）的风险增加。
甲状腺功能亢进患者在诊断前后均有更高的住院治疗精神疾病和使用抗精神病药、抗抑郁药和抗焦虑药的风险。
