亨氏单位能否预测药物排石治疗的成功率？
Can the Hounsfield unit predict the success of medically expulsive therapy?
作者信息
Erturhan Sakip, Bayrak Omer, Mete Ahmet, Seckiner Ilker, Urgun Gokhan, Sarica Kemal
机构信息
Department of Urology, Gaziantep University, Gaziantep, Turkey;
出版信息
Can Urol Assoc J. 2013 Nov-Dec;7(11-12):E677-80. doi: 10.5489/cuaj.352.
BACKGROUND
We investigate the predictability of medical expulsive therapy (MET) success with alpha blockers based on Hounsfield unit (HU) values and Hounsfield density (HD) values measured by computed tomography (CT) for distal ureteral stones.
METHODS
Between July 2011 and May 2012, 44 patients (19 female and 25 male) with 5- to 10-mm stones in the distal ureters were included in this randomized prospective study. Non-contrast CT examinations were performed in these patients. HU and HD values of stones were calculated. Doxazosine, 4 mg/day orally, was administered as a single dose to all patients for MET.
RESULTS
Patients were divided into 2 groups. Group 1 included 18 patients (43.9%) with dropped stones with MET. Group 2 included 23 patients (56.1%) with no stone passage with MET. In Group 1, the mean stone size was 7.7 mm, the mean HU was 507, and the HD was 53.04/mm. In Group 2, the mean stone size was 8.25 mm, the mean HU was 625, and the mean HD was 61.54/mm. The HU and HD values in Group 2 were higher than in Group 1. However, there was no statistically significant difference (p = 0.85 and 0.93 for HU and HD, respectively).
INTERPRETATION
We found that HU and HD values cannot be used to predict the chances of success for MET. Although the sample size is appropriate for the study, further comparative studies involving more patients are warranted.
背景
我们基于计算机断层扫描（CT）测量的输尿管远端结石的亨氏单位（HU）值和亨氏密度（HD）值，研究使用α受体阻滞剂进行药物排石疗法（MET）成功的可预测性。
方法
在2011年7月至2012年5月期间，本随机前瞻性研究纳入了44例输尿管远端有5至10毫米结石的患者（19例女性和25例男性）。对这些患者进行了非增强CT检查。计算结石的HU值和HD值。所有患者均口服多沙唑嗪4毫克/天作为单一剂量进行MET。
结果
患者分为两组。第1组包括18例（43.9%）通过MET排出结石的患者。第2组包括23例（56.1%）未通过MET排出结石的患者。在第1组中，平均结石大小为7.7毫米，平均HU为507，HD为53.04/毫米。在第2组中，平均结石大小为8.25毫米，平均HU为625，平均HD为61.54/毫米。第2组的HU和HD值高于第1组。然而，差异无统计学意义（HU和HD的p值分别为0.85和0.93）。
解读
我们发现HU和HD值不能用于预测MET成功的可能性。尽管样本量适合该研究，但仍需要进行更多涉及更多患者的比较研究。
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