Sreeshyla Huchanahalli S, Shashidara Raju, Sudheendra Udyavara Sridhara
Department of Oral Pathology and Microbiology, JSS Dental College and Hospital, Mysore, India.
Anal Quant Cytopathol Histpathol. 2013 Oct;35(5):273-7.
To evaluate the morphometry of AgNORs in odontogenic cysts and to compare their biologic behavior to determine whether AgNOR morphometry is helpful in predicting the behavior.
Ten cases each of odontogenic keratocyst (OKC), dentigerous cyst (DC) and radicular cyst (RC) were stained with silver nitrate. Morphometric analysis of 100 selected epithelial and connective tissue cells was done to record their nuclear volume, nuclear perimeter, contour index of the nucleus, AgNOR count, AgNOR proportion and single AgNOR volume. The results were statistically analyzed using ANOVA.
AgNOR count, nuclear volume and nuclear perimeter were greatest in the OKC followed by DC and RC, suggesting that these parameters differentiate between the aggressive and less aggressive odontogenic cysts. Single AgNOR volume and AgNOR proportion were greatest in the RC followed by OKC and DC, respectively.
Results of our study taken in isolation point to AgNOR count as the most reliable factor in differentiating between aggressive and nonaggressive odontogenic cysts.
评估牙源性囊肿中嗜银核仁组织区（AgNORs）的形态计量学，并比较其生物学行为，以确定AgNOR形态计量学是否有助于预测其行为。
对10例牙源性角化囊肿（OKC）、含牙囊肿（DC）和根尖囊肿（RC）分别用硝酸银染色。对100个选定的上皮和结缔组织细胞进行形态计量分析，记录其核体积、核周长、核轮廓指数、AgNOR计数、AgNOR比例和单个AgNOR体积。结果采用方差分析进行统计学分析。
OKC中的AgNOR计数、核体积和核周长最大，其次是DC和RC，表明这些参数可区分侵袭性和非侵袭性牙源性囊肿。单个AgNOR体积和AgNOR比例在RC中最大，其次分别是OKC和DC。
我们单独进行的研究结果表明，AgNOR计数是区分侵袭性和非侵袭性牙源性囊肿的最可靠因素。
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