福斯高林单独及与异丙肾上腺素联用对豚鼠肺组织匀浆抗原诱导的组胺释放的影响。
Effects of forskolin alone and in combination with isoproterenol on antigen-induced histamine release from guinea-pig minced lung.
作者信息
Undem B J, Buckner C K
出版信息
Arch Int Pharmacodyn Ther. 1986 May;281(1):110-9.
PMID:2428320
Abstract
Forskolin inhibited antigen-induced release of histamine and leukotrienes from minced guinea-pig lung. The apparent potency of forskolin was similar for the two measured responses. Combination of forskolin with isoproterenol resulted in an additive inhibition of histamine release. The results support the contention that increases in cyclic AMP can inhibit antigen-induced histamine release, but a two-site model for forskolin does not appear to be operative in this system.
摘要
福司可林抑制抗原诱导的豚鼠肺匀浆中组胺和白三烯的释放。对于所检测的两种反应，福司可林的表观效力相似。福司可林与异丙肾上腺素联合使用可对组胺释放产生相加性抑制作用。这些结果支持环磷酸腺苷（cAMP）升高可抑制抗原诱导的组胺释放这一观点，但在该系统中，福司可林的双位点模型似乎并不起作用。
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