Gomes F, Teixeira P, Oliveira R
a Centre of Biological Engineering, IBB - Institute for Biotechnology and Bioengineering, University of Minho , Braga , Portugal.
Biofouling. 2014 Feb;30(2):131-41. doi: 10.1080/08927014.2013.848858. Epub 2013 Nov 28.
Staphylococcus epidermidis is nowadays regarded as the most frequent cause of nosocomial infections and indwelling medical device-associated infections. One of the features that contributes to the success of this microorganism and which is elemental to the onset of pathogenesis is its ability to form biofilms. Cells in this mode of growth are inherently more resistant to antimicrobials. Seeking to treat staphylococcal-related infections and to prevent their side effects, such as the significant morbidity and health care costs, many efforts are being made to develop of new and effective antistaphylococcal drugs. Indeed, due to its frequency and extreme resistance to treatment, staphylococcal-associated infections represent a serious burden for the public health system. This review will provide an overview of some conventional and emerging anti-biofilm approaches in the management of medical device-associated infections related to this important nosocomial pathogen.
表皮葡萄球菌如今被认为是医院感染和留置医疗器械相关感染最常见的病因。这种微生物成功的一个因素以及发病机制的基本要素是其形成生物膜的能力。以这种生长方式存在的细胞本质上对抗菌药物更具抗性。为了治疗葡萄球菌相关感染并预防其副作用，如显著的发病率和医疗费用，人们正在努力研发新的有效抗葡萄球菌药物。事实上，由于其感染频率高且治疗难度极大，葡萄球菌相关感染给公共卫生系统带来了沉重负担。本综述将概述一些传统和新兴的抗生物膜方法，用于管理与这种重要的医院病原体相关的医疗器械相关感染。
