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近期降低抗生素耐药性的方法：分子机制。

Recent Approaches for Downplaying Antibiotic Resistance: Molecular Mechanisms.

机构信息

Department of Basic Sciences, University of Veterinary and Animal Sciences Lahore, Narowal Campus, 51600 Narowal, Pakistan.

Department of Biochemistry, Bahauddin Zakariya University, Multan 60800, Pakistan.

出版信息

Biomed Res Int. 2023 Jan 23;2023:5250040. doi: 10.1155/2023/5250040. eCollection 2023.

DOI:10.1155/2023/5250040
PMID:36726844
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9886476/
Abstract

Antimicrobial resistance (AMR) is a ubiquitous public health menace. AMR emergence causes complications in treating infections contributing to an upsurge in the mortality rate. The epidemic of AMR in sync with a high utilization rate of antimicrobial drugs signifies an alarming situation for the fleet recovery of both animals and humans. The emergence of resistant species calls for new treatments and therapeutics. Current records propose that health drug dependency, veterinary medicine, agricultural application, and vaccination reluctance are the primary etymology of AMR gene emergence and spread. Recently, several encouraging avenues have been presented to contest resistance, such as antivirulent therapy, passive immunization, antimicrobial peptides, vaccines, phage therapy, and botanical and liposomal nanoparticles. Most of these therapies are used as cutting-edge methodologies to downplay antibacterial drugs to subdue the resistance pressure, which is a featured motive of discussion in this review article. AMR can fade away through the potential use of current cutting-edge therapeutics, advancement in antimicrobial susceptibility testing, new diagnostic testing, prompt clinical response, and probing of new pharmacodynamic properties of antimicrobials. It also needs to promote future research on contemporary methods to maintain host homeostasis after infections caused by AMR. Referable to the microbial ability to break resistance, there is a great ultimatum for using not only appropriate and advanced antimicrobial drugs but also other neoteric diverse cutting-edge therapeutics.

摘要

抗微生物药物耐药性（AMR）是一种普遍存在的公共卫生威胁。AMR 的出现导致感染治疗变得复杂，导致死亡率上升。AMR 的流行与抗菌药物的高使用率同时出现，对动物和人类的快速恢复构成了令人震惊的局面。耐药物种的出现需要新的治疗方法和疗法。目前的记录表明，卫生药物依赖、兽医学、农业应用和疫苗接种犹豫是 AMR 基因出现和传播的主要病因。最近，已经提出了几种令人鼓舞的方法来对抗耐药性，例如抗病毒疗法、被动免疫、抗菌肽、疫苗、噬菌体疗法以及植物和脂质体纳米颗粒。这些疗法中的大多数都被用作前沿方法，以减轻抗菌药物的使用，从而减轻耐药性压力，这是本文讨论的一个特色主题。通过当前前沿疗法的潜在应用、抗菌药物敏感性测试的进展、新的诊断测试、及时的临床反应以及对抗微生物药物新的药效学特性的探索，AMR 是可以消除的。它还需要促进对当代方法的未来研究，以维持 AMR 感染后宿主的体内平衡。鉴于微生物打破耐药性的能力，不仅需要使用适当和先进的抗菌药物，还需要使用其他新的多样化前沿疗法。

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