Rowe Casey, Spelman Lynda, Oziemski Margaret, Ryan Alexander, Manoharan Shobhan, Wilson Perry, Daubney Michael, Scott James
University of Queensland Centre for Clinical Research, Brisbane, Queensland, Australia.
Australas J Dermatol. 2014 May;55(2):162-7. doi: 10.1111/ajd.12117. Epub 2013 Nov 28.
Acne is a common condition among adolescents and has the potential to negatively impact on the psychological well-being of those who suffer from it. In particular, depression and suicidal ideation are more common in adolescents with acne. Successful treatment of acne can improve the quality of life and reduce levels of anxiety and depression in these individuals. The current treatment of choice for severe or refractive acne is isotretinoin, a retinoid. While the possible causal association between isotretinoin and mental illness remains a controversial topic, a recent systematic review has presented evidence to support this relationship. In light of this evidence, a group of dermatologists and psychiatrists have collaborated to develop these recommendations to aid the safe prescribing of isotretinoin in adolescents. These clinical suggestions are aimed at practitioners in both disciplines to increase awareness of the current evidence in support of the association between isotretinoin and adolescent depression.
痤疮是青少年中的常见病症，有可能对患者的心理健康产生负面影响。特别是，抑郁症和自杀意念在患有痤疮的青少年中更为常见。成功治疗痤疮可以改善生活质量，并降低这些人的焦虑和抑郁水平。目前治疗重度或难治性痤疮的首选药物是异维甲酸，一种维甲酸类药物。虽然异维甲酸与精神疾病之间可能的因果关系仍是一个有争议的话题，但最近的一项系统评价已提出证据支持这种关系。鉴于这一证据，一组皮肤科医生和精神科医生合作制定了这些建议，以帮助在青少年中安全地开具异维甲酸处方。这些临床建议针对这两个学科的从业者，以提高对目前支持异维甲酸与青少年抑郁症之间关联的证据的认识。
