Bosslet K, Sedlacek H H
Behring Inst Mitt. 1986 Jun(80):42-7.
The clinical role of MAbs in the serum and immunohistochemical diagnostics is already established. Their potential usefulness for immunoscintigraphy is in the progress of evaluation and will probably be introduced in nuclear medical routine very soon. First clinical trials with special untagged or radiolabelled MAbs indicate their potency for the therapy of certain tumors. Clinical investigations with drug MAb conjugates have been started and will hopefully reveal significant therapeutic effects.
单克隆抗体在血清学和免疫组织化学诊断中的临床作用已经确立。它们在免疫闪烁成像方面的潜在用途正在评估中，可能很快会引入核医学常规检查。首次使用特殊的未标记或放射性标记单克隆抗体进行的临床试验表明了它们对某些肿瘤的治疗潜力。针对药物-单克隆抗体偶联物的临床研究已经启动，有望揭示显著的治疗效果。
