Law W Phillip, Fiumara Frank, Fong William, Macfarlane David J
Department of Nuclear Medicine and PET, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia; Medical Imaging Department, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
J Med Imaging Radiat Oncol. 2013 Dec;57(6):680-3. doi: 10.1111/1754-9485.12069. Epub 2013 May 3.
Gallium-68 ((68) Ga)-labelled somatostatin analogue imaging by positron emission tomography (PET) is increasingly replacing single photon (such as (111) In-labelled octreotide) imaging in the detection and staging of carcinoid and other neuroendocrine tumours. Among other tissues, pituitary uptake of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-octreotate (DOTA-TATE) and other somatostatin analogues is physiological. DOTA-TATE also accumulates in meningiomas, which have a high density of somatostatin receptor expression. The combination of pituitary and skull base meningioma uptake results in a characteristic 'double hot spot' appearance, which indicates the presence of a meningioma. This is a case of a middle-aged woman who underwent (68) Ga-DOTA-TATE PET for confirmation and staging of clinically suspected carcinoid tumour, in whom a skull base meningioma was incidentally discovered. With the increasing use of PET in the management of neuroendocrine tumours - and the not infrequent occurrence of meningiomas - the appearance of meningiomas on somatostatin analogue imaging should be one with which reporting clinicians are familiar.
通过正电子发射断层扫描(PET)进行的镓-68(⁶⁸Ga)标记的生长抑素类似物成像,在类癌和其他神经内分泌肿瘤的检测及分期中越来越多地取代了单光子成像(如¹¹¹In标记的奥曲肽)。在其他组织中,垂体对1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸-奥曲肽(DOTA-TATE)和其他生长抑素类似物的摄取是生理性的。DOTA-TATE也会在脑膜瘤中蓄积,脑膜瘤具有高密度的生长抑素受体表达。垂体和颅底脑膜瘤摄取的结合导致特征性的“双热点”表现,这表明存在脑膜瘤。这是一例中年女性,因临床怀疑类癌肿瘤进行⁶⁸Ga-DOTA-TATE PET检查以进行确诊和分期,在此过程中偶然发现了颅底脑膜瘤。随着PET在神经内分泌肿瘤管理中的使用增加——以及脑膜瘤并不罕见的发生——生长抑素类似物成像上脑膜瘤的表现应该是报告临床医生所熟悉的。