Department of Radiation Oncology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Int J Radiat Oncol Biol Phys. 2013 Jan 1;85(1):68-73. doi: 10.1016/j.ijrobp.2012.03.021. Epub 2012 May 9.
To investigate the potential impact of 68Ga-DOTATOC positron emission tomography (68Ga-DOTATOC-PET) in addition to magnetic resonance imaging (MRI) and computed tomography (CT) for retrospectively assessing the gross tumor volume (GTV) delineation of meningiomas of the skull base in patients treated with fractionated stereotactic radiation therapy (FSRT).
The study population consisted of 48 patients with 54 skull base meningiomas, previously treated with FSRT. After scans were coregistered, the GTVs were first delineated with MRI and CT data (GTVMRI/CT) and then by PET (GTVPET) data. The overlapping regions of both datasets resulted in the GTVcommon, which was enlarged to the GTVfinal by adding volumes defined by only one of the complementary modalities (GTVMRI/CT-added or GTVPET-added). We then evaluated the contribution of conventional imaging modalities (MRI, CT) and 68Ga-DOTATOC-PET to the GTVfinal, which was used for planning purposes.
Forty-eight of the 54 skull base lesions in 45 patients showed increased 68Ga-DOTATOC uptake and were further analyzed. The mean GTVMRI/CT and GTVPET were approximately 21 cm3 and 25 cm3, with a common volume of approximately 15 cm3. PET contributed a mean additional GTV of approximately 1.5 cm3 to the common volume (16%±34% of the GTVcommon). Approximately 4.5 cm3 of the GTVMRI/CT was excluded from the contribution to the common volume. The resulting mean GTVfinal was significantly smaller than both the GTVMRI/CT and the GTVPET. Compared with the initial GTVMRI/CT, the addition of 68Ga-DOTATOC-PET resulted in more than 10% modification of the size of the GTVfinal in 32 (67%) meningiomas
68Ga-DOTATOC-PET/CT seems to improve the target volume delineation in skull base meningiomas, often leading to a reduction of GTV compared with results from conventional imaging (MRI and CT).
研究 68Ga-DOTATOC 正电子发射断层扫描（68Ga-DOTATOC-PET）结合磁共振成像（MRI）和计算机断层扫描（CT）对颅底脑膜瘤患者行分割立体定向放疗（FSRT）后大体肿瘤体积（GTV）勾画的潜在影响。
研究人群包括 48 例 54 个颅底脑膜瘤患者，这些患者均接受过 FSRT 治疗。在对扫描进行配准后，首先使用 MRI 和 CT 数据（GTVMRI/CT）勾画 GTV，然后使用 PET 数据（GTVPET）勾画 GTV。两个数据集的重叠区域产生 GTVcommon，然后通过向其添加仅来自一种互补方式（GTVMRI/CT-added 或 GTVPET-added）定义的体积，将 GTVcommon 扩大到 GTVfinal。我们评估了常规成像方式（MRI、CT）和 68Ga-DOTATOC-PET 对 GTVfinal 的贡献，该体积用于计划目的。
在 45 例患者的 54 个颅底病变中，有 48 个病变显示 68Ga-DOTATOC 摄取增加，进一步对其进行了分析。GTVMRI/CT 和 GTVPET 的平均值分别约为 21 cm3 和 25 cm3，GTVcommon 的平均值约为 15 cm3。PET 为 GTVcommon 贡献了约 1.5 cm3 的额外 GTV（占 GTVcommon 的 16%±34%）。GTVMRI/CT 中有约 4.5 cm3 的体积未被纳入 GTVcommon。最终的 GTVfinal 明显小于 GTVMRI/CT 和 GTVPET。与初始 GTVMRI/CT 相比，68Ga-DOTATOC-PET 的添加导致 32 个（67%）脑膜瘤的 GTVfinal 大小的修改超过 10%。
68Ga-DOTATOC-PET/CT 似乎可以改善颅底脑膜瘤的靶区勾画，通常会导致 GTV 比常规成像（MRI 和 CT）的结果更小。
