Department of Neurosurgery, Osaka Medical College, Japan.
Photodiagnosis Photodyn Ther. 2013 Dec;10(4):379-81. doi: 10.1016/j.pdpdt.2013.03.004. Epub 2013 May 2.
We recently developed a surgical loupe system for observing the fluorescence emitted by protoporphyrin IX (PpIX), a metabolite of 5-aminolevulinic acid.
This system used a semiconductor laser as the excitation light source. A compact, transparent, and ultraviolet cut-off filter was mounted on an eyepiece lens, which did not require filter on-off manipulation.
Good quality protoporphyrin IX fluorescence was acquired using the surgical loupe system during glioblastoma resection, which was nearly identical to that acquired by fluorescent microscopy. In addition, surgeons can perform ordinary surgical procedures using this surgical loupe system under white light.
This surgical loupe system enables the detection of PpIX fluorescence during resection of high-grade glioma. Further evaluations of this system are required to determine the extent of surgical resection before its practical application.
我们最近开发了一种用于观察原卟啉 IX（PpIX）荧光的手术放大镜系统，PpIX 是 5-氨基酮戊酸的代谢产物。
该系统使用半导体激光作为激发光源。一个紧凑、透明且带紫外线截止滤光片的目镜安装在其上，无需进行滤光片的开/关操作。
在脑胶质瘤切除过程中，使用手术放大镜系统获得了高质量的原卟啉 IX 荧光，与荧光显微镜获得的荧光几乎相同。此外，外科医生可以在白光下使用该手术放大镜系统进行普通手术操作。
该手术放大镜系统可用于检测高级别脑胶质瘤切除过程中的 PpIX 荧光。在实际应用之前，需要进一步评估该系统，以确定手术切除的范围。
