Max Planck Institute for Infection Biology, Lymphocyte Development Group, Berlin, Germany.
German Rheumatism Research Center (DRFZ), A Leibniz Institute, Berlin, Germany.
Immunol Lett. 2014 Jan-Feb;157(1-2):60-3. doi: 10.1016/j.imlet.2013.11.011. Epub 2013 Nov 24.
B lymphocyte development in the mouse begins with the generation of long-term reconstituting, pluripotent hematopoietic stem cells, over multipotent myeloid/lymphoid progenitors and common lymphoid progenitors to B-lineage committed pro/pre B and pre B cells, which first express pre B cell receptors and then immunoglobulins, B cell receptors, to generate the repertoires of peripheral B cells. This development is influenced and guided by cells of non-hematopoietic and hematopoietic origins. We review here some of the recent developments, and our contributions in this fascinating field of developmental immunology.
小鼠 B 淋巴细胞的发育始于长期重建成体、多能造血干细胞的生成，经过多能髓系/淋巴祖细胞和共同淋巴祖细胞，到 B 谱系定向的 pro/pre B 和 pre B 细胞，这些细胞首先表达 pre B 细胞受体，然后表达免疫球蛋白、B 细胞受体，从而产生外周 B 细胞的库。这种发育受到非造血细胞和造血细胞的影响和指导。我们在这里回顾了一些最近的发展，以及我们在这个迷人的发育免疫学领域的贡献。
