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肺部药物毒性:一例由帕罗西汀引起的复发性弥漫性肺泡损伤病例报告

Pulmonary drug toxicity: presentation of a case of recurrent diffuse alveolar damage caused by paroxetine.

作者信息

Antonello Nicolini, Sergio Lanata, Andrea Tironi, Cornelius Barlascini

机构信息

1Respiratory Diseases Unit, Hospital of Sestri Levante, Sestri Levante, Italy; 2Histopathology Unit, Hospital of Sestri Levante, Sestri Levante, Italy; 3Department of Pathology, Ospedali Civili Brescia, Brescia, Italy; and 4Forensic Medicine ASL4, Chiavari, Italy.

出版信息

Am J Ther. 2015 Mar-Apr;22(2):e43-7. doi: 10.1097/MJT.0b013e31829ed1f2.

Abstract

Pulmonary drug toxicity is being diagnosed more often as a cause of acute and chronic lung disease. Numerous agents including cytotoxic and noncytotoxic drugs have the potential to cause pulmonary toxicity. Recurrent diffuse alveolar damage is a rare manifestation of drug toxicity. We described an extremely rare case of recurrent diffuse alveolar damage caused by the antidepressant drug (paroxetine) resolved by a definitive suspension of the drug, after a recurrent respiratory failure because of inadvertently administering the drug.

摘要

作为急慢性肺部疾病的病因,肺药物毒性的诊断越来越常见。包括细胞毒性和非细胞毒性药物在内的众多药物都有可能导致肺毒性。复发性弥漫性肺泡损伤是药物毒性的一种罕见表现。我们描述了一例极其罕见的由抗抑郁药(帕罗西汀)引起的复发性弥漫性肺泡损伤病例,在因不慎服用该药物导致反复呼吸衰竭后,通过明确停用该药物而得到解决。

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