medical student, New York University School of Medicine, New York.
Department of Pathology, New York University Langone Medical Center, New York3Ronald O. Perelman Department of Dermatology, New York University Langone Medical Center, New York.
JAMA Dermatol. 2014 Feb;150(2):182-4. doi: 10.1001/jamadermatol.2013.7371.
IMPORTANCE Medications as well as chemical and food exposures have been causally linked to the development of pigmented purpuric dermatosis (PPD). We describe herein what is to our knowledge the first reported case of isotretinoin-induced PPD. OBSERVATIONS A woman in her 30s presented with purpura annularis telangiectodes of Majocchi on the lower extremities 2 months after initiating isotretinoin for the treatment of refractory nodulocystic acne. CONCLUSIONS AND RELEVANCE We believe isotretinoin was the most likely causative agent in this case because the lesions began after initiation of isotretinoin treatment and resolved shortly after its termination, and the pathologic findings were consistent with other described cases of drug-induced PPD. The lesions have continued to fade, and no new lesions have developed in a 3-month follow-up period. Drug-induced PPD is distinct from idiopathic PPD, and it is important to consider isotretinoin as a potential inciting agent.
药物、化学物质和食物暴露已被确定与色素性紫癜性皮炎（PPD）的发生有关。我们在此描述了一个据我们所知的首例假体醇诱导的 PPD 病例。
一名 30 多岁的女性在开始使用异维 A 酸治疗难治性结节性囊肿性痤疮 2 个月后，下肢出现 Majocchi 环形毛细血管扩张性紫癜。
我们认为异维 A 酸极有可能是导致该病例的原因，因为皮损在开始异维 A 酸治疗后出现，并且在停药后很快消退，且病理发现与其他描述的药物诱导 PPD 病例一致。皮损持续消退，在 3 个月的随访期间没有出现新的皮损。药物诱导的 PPD 与特发性 PPD 不同，因此将异维 A 酸视为潜在的诱发因素很重要。
