Zeng Huahui, Zhang Huabei, Wu Xiangxiang, Chao Fangfang, Yu Gang, Zhang Liqing, Jiang Han, Liu Hongbiao, Hou Haifeng, Zhan Hongwei, Zhang Hong, Tian Mei
Department of Nuclear Medicine, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China, 310009; Key Laboratory of Radiopharmaceuticals of Ministry of Education, College of Chemistry, Beijing Normal University, Beijing, China, 100875.
J Labelled Comp Radiopharm. 2013 Jan;56(1):1-5. doi: 10.1002/jlcr.2987. Epub 2012 Dec 7.
This study reports the synthesis and evaluation studies of 6'-cyclopentadienyl tricarbonyl technetium-99m 6'-oxo-11-(hexanamide)undecanoic acid (1). 1 was prepared with 26.5 ± 4.3% of radiochemical yield and more than 98% of radiochemical purity. Tissue distribution in mice showed that high radioactivity accumulated in the heart with moderate clearance. However, unfortunately, similar to those of other technetium-labeled fatty acid analogs, the biodistribution studies of 1 in mice showed poor heart-to-blood ratios, which suggested that 1 cannot be used as myocardial imaging agent, and it may provide a theoretical basis or a lab experience for corresponding fatty acid tracers studies.
