Sun L Z, Waltenbaugh C
Cell Immunol. 1986 Apr 1;98(2):375-85. doi: 10.1016/0008-8749(86)90297-2.
Injection of responder mice with poly(Glu60Ala30Tyr10) (GAT) followed by immunization with GAT-methylated bovine serum albumin (GATMBSA) selectively suppresses anti-MBSA plaque-forming cell (PFC) and delayed hypersensitivity (DTH) reactions. Conversely, MBSA injection followed by GATMBSA immunization suppresses anti-GAT PFC and DTH, while anti-MBSA responses remain intact. Suppression occurs for doses of antigen which are optimally immunogenic. The suppression is specific and does not act in a bystander fashion. These results demonstrate that epitope-specific regulation is reciprocal, is not limited to humoral responses, and is not limited to molecules of low molecular weight.
给反应小鼠注射聚（Glu60Ala30Tyr10）（GAT），随后用GAT甲基化牛血清白蛋白（GATMBSA）进行免疫，可选择性地抑制抗MBSA斑块形成细胞（PFC）和迟发型超敏反应（DTH）。相反，先注射MBSA，然后用GATMBSA免疫，则会抑制抗GAT PFC和DTH，而抗MBSA反应保持完整。对于具有最佳免疫原性的抗原剂量会出现抑制作用。这种抑制是特异性的，不会以旁观者方式起作用。这些结果表明，表位特异性调节是相互的，不限于体液反应，也不限于低分子量分子。
