Långström B, Karimi F, Watanabe Y
Uppsala University, Department of Biochemistry and Organic Chemistry, Faculty of Technology and Science, Uppsala, Sweden; Imperial College, Neuropsychopharmacology Unit, Centre for Pharmacology and Therapeutics, Division of Experimental Medicine, London, UK; University of Southern Denmark, Institute of Clinical Research, Department of Nuclear Medicine, PET and Cyclotron Unit, Odense, Denmark.
J Labelled Comp Radiopharm. 2013 Mar-Apr;56(3-4):251-62. doi: 10.1002/jlcr.3033.
In the article, the strategy and synthesis of some endogenous compounds labeled mainly with (11) C are presented. There are some examples illustrating how endogenous labeled compounds in connection with positron emission tomography have unique properties to describe various biological processes, and a few examples of the use of tracers labeled with (13) N and (15) O are also discussed. Labeled endogenous compounds may be an important asset to describe the conditions and the status of biological systems and might therefore be a key for the future search of individualized medicine.
本文介绍了一些主要用¹¹C标记的内源性化合物的策略和合成方法。有一些例子说明了与正电子发射断层扫描相关的内源性标记化合物如何具有描述各种生物过程的独特性质，同时也讨论了一些用¹³N和¹⁵O标记的示踪剂的使用实例。标记的内源性化合物可能是描述生物系统状况和状态的重要资产，因此可能是未来个性化医学研究的关键。
