[15,16-³H]β-芬太尼透胺的合成
Synthesis of [15, 16- ³H] beta-funaltrexamine.
作者信息
Filer Crist N, Seguin Richard J
机构信息
PerkinElmer Life Sciences & Technology Inc., 940 Winter Street, Waltham, MA, 02451, USA.
出版信息
J Labelled Comp Radiopharm. 2013 May 15;56(5):310-1. doi: 10.1002/jlcr.3050. Epub 2013 Apr 24.
PMID:24285378
Abstract
Beta-funaltrexamine is a unique irreversible antagonist for the mu-opiate receptor and would be useful as a tritiated radioligand. Starting from high specific activity [15, 16-³H] naltrexone, [15, 16-³H] beta-funaltrexamine was synthesized and characterized by means of a two-step reductive amination-acylation process.
摘要
β-氟纳曲胺是一种独特的μ-阿片受体不可逆拮抗剂，可用作氚标记的放射性配体。以高比活度的[15,16-³H]纳曲酮为起始原料，通过两步还原胺化-酰化过程合成并表征了[15,16-³H]β-氟纳曲胺。
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