Amani A M
Department of Chemistry, Shiraz University of Technology, Shiraz, Iran.
Drug Res (Stuttg). 2014 Aug;64(8):420-3. doi: 10.1055/s-0033-1361091. Epub 2013 Nov 27.
Some novel Pyrrolo [2,3-f] Indole-3,7-Dicarbonitrile derivatives (1-5) were synthesized using chloranil, malononitrile and anilines. The structures of the newly synthesized compounds were characterized by elemental analysis, FT-IR, (1)H- and (13)C-NMR and mass spectroscopy. These compounds were screened for in vitro antibacterial and antifungal activities against some human pathogenic micro-organisms by employing the disc diffusion technique. Some of the compounds showed moderate to good biological activities when compared with standard drugs.
使用四氯苯醌、丙二腈和苯胺合成了一些新型吡咯并[2,3-f]吲哚-3,7-二腈衍生物（1-5）。通过元素分析、傅里叶变换红外光谱（FT-IR）、氢核磁共振（¹H-NMR）、碳核磁共振（¹³C-NMR）和质谱对新合成化合物的结构进行了表征。采用纸片扩散法对这些化合物针对一些人类致病微生物的体外抗菌和抗真菌活性进行了筛选。与标准药物相比，其中一些化合物表现出中度至良好的生物活性。
