Ren Sumei, Hesk David, McNamara Paul, Koharski David, Hendershot Sharon
Merck Research Laboratories, 126 E. Lincoln Avenue, PO Box 2000, Rahway, NJ, 07065, USA.
J Labelled Comp Radiopharm. 2013 Jul-Aug;56(9-10):480-4. doi: 10.1002/jlcr.3080. Epub 2013 Aug 24.
The syntheses of [(3) H]SCH 444877, [(2) H4 ]SCH 444877, and [(14) C]SCH 444877 are described. [(3) H]SCH 444877 was prepared in three steps from tritium gas. [(2) H4 ]SCH 444877 was synthesized from [(2) H4 ]ethanolamine in four steps with an overall yield of 40%. [(14) C]SCH 444877 was prepared from barium [(14) C]cyanamide in 10 steps with an overall yield of 8.1%.
描述了[(3)H]SCH 444877、[(2)H4]SCH 444877和[(14)C]SCH 444877的合成方法。[(3)H]SCH 444877由氚气分三步制备。[(2)H4]SCH 444877由[(2)H4]乙醇胺分四步合成，总产率为40%。[(14)C]SCH 444877由[(14)C]氰氨化钡分十步制备，总产率为8.1%。
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