在侧链中选择性地进行H-和H-标记的3'-卤代酪胺的酶促合成。
Enzymatic syntheses of 3'-halotyramines, selectively H- and H-labeled in the side chain.
作者信息
Pająk Małgorzata, Kańska Marianna
机构信息
Warsaw University, Department of Chemistry, Pasteur 1 Str., 02-093 Warsaw, Poland.
Medical University of Warsaw, 2nd Faculty of Medicine, Department of Biochemistry, 61 Zwirki i Wigury Av., 02-091 Warsaw, Poland.
出版信息
Appl Radiat Isot. 2018 Jan;131:8-12. doi: 10.1016/j.apradiso.2017.10.032. Epub 2017 Oct 16.
3'-Halotyramines, stereo-selectively labeled with deuterium and tritium, in the (1R) or (1S) position were synthesized using enzymatic methods. The isotopomers labeled in the (1R) position were synthesized by enzymatic decarboxylation of an appropriate 3'-halo-L-tyrosine in deuterated or tritiated incubation medium. The isotopomers labeled in the (1S) position were synthesized by decarboxylation of an appropriate 3'-halo-L-tyrosine, labeled with deuterium or tritium in the α-position of the side chain.
使用酶法合成了在（1R）或（1S）位置立体选择性地用氘和氚标记的3'-卤代酪胺。在氘代或氚代孵育培养基中，通过适当的3'-卤代-L-酪氨酸的酶促脱羧反应合成了在（1R）位置标记的同位素异构体。在（1S）位置标记的同位素异构体是通过侧链α-位用氘或氚标记的适当3'-卤代-L-酪氨酸的脱羧反应合成的。
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