Delmonte V C, Alberti O, Saldiva P H
Chest. 1986 Oct;90(4):524-7. doi: 10.1378/chest.90.4.524.
Forty one cases of large cell anaplastic carcinoma of the lung (LCACL) were investigated by electron microscopy and immunoperoxidase studies for cytokeratin, enolase, and carcinoembryonic antigen. The results indicated that these neoplasias, grouped as an unique entity by ordinary histopathologic findings, may be further divided into five groups as follows: squamous, adenomatous, adenosquamous, neuroendocrine, and undifferentiated. The authors suggest that this subclassification may be useful in treatment orientation and in the prognostic evaluation of these neoplasias.
通过电子显微镜以及针对细胞角蛋白、烯醇化酶和癌胚抗原的免疫过氧化物酶研究，对41例肺大细胞间变性癌（LCACL）进行了调查。结果表明，这些肿瘤通过普通组织病理学检查结果归为一个独特的实体，可进一步分为以下五组：鳞状、腺瘤样、腺鳞、神经内分泌和未分化型。作者认为这种亚分类可能有助于这些肿瘤的治疗导向和预后评估。
